Skill Library¶
ClawBio ships with 24+ skills spanning pharmacogenomics, population genetics, single-cell biology, variant annotation, and more. Every skill includes demo data for instant testing.
Production-Ready Skills¶
PharmGx Reporter
Pharmacogenomics report from 23andMe/AncestryDNA/VCF data. CPIC guideline-backed drug-gene interactions.
scRNA Orchestrator
End-to-end single-cell RNA-seq pipeline: QC, normalisation, clustering, marker genes, doublet removal.
Equity Scorer (HEIM)
Health Equity Impact Metric — measures genomic dataset diversity and population representation.
NutriGx Advisor
Personalised nutrition report from genetic data. 40+ nutritionally-relevant SNPs.
Genome Compare
Pairwise genome comparison with IBS scoring. Compare against George Church's genome.
GWAS PRS
Polygenic risk scores from consumer genetic data. 6 curated traits.
GWAS Lookup
Federated variant query across 9 genomic databases.
Illumina Bridge
Integration with Illumina Connected Analytics (ICA) platform.
Galaxy Bridge
Search, inspect, and run Galaxy tools from ClawBio.
RNA-seq DE
Bulk and pseudo-bulk RNA-seq differential expression with PyDESeq2.
Additional Skills¶
| Skill | Domain | Status |
|---|---|---|
| Bio Orchestrator | Routing | Production |
| ClinPGx | Pharmacogenomics | Production |
| Profile Report | Multi-skill | Production |
| UKB Navigator | UK Biobank | Production |
| Ancestry PCA | Population genetics | SKILL.md only |
| Metagenomics | Microbiome | SKILL.md only |
| Semantic Similarity | Research gaps | SKILL.md only |
| VCF Annotator | Variant annotation | SKILL.md only |
| Lit Synthesizer | Literature | SKILL.md only |
| Struct Predictor | Protein structure | SKILL.md only |
| Repro Enforcer | Reproducibility | SKILL.md only |
| Seq Wrangler | Sequence QC | SKILL.md only |
| Labstep | Lab notebook | SKILL.md only |
| scRNA Embedding | Single-cell | Production |
Run Any Demo¶
Every skill has demo data. Just add --demo:
python3 skills/pharmgx-reporter/pharmgx_reporter.py \
--input skills/pharmgx-reporter/demo_patient.txt --output /tmp/demo
python3 skills/gwas-prs/gwas_prs.py --demo --output /tmp/demo
python3 skills/scrna-orchestrator/scrna_orchestrator.py --demo --output /tmp/demo
python3 skills/clinpgx/clinpgx.py --demo --output /tmp/demo