Genome Compare

Compare two personal genomes and compute identity-by-state (IBS) similarity. The demo compares Manuel Corpas against George Church using their public 23andMe data and provides ancestry estimation.

Quick Demo

python3 skills/genome-compare/genome_compare.py \
  --demo \
  --output /tmp/demo

CLI Reference

# Compare your genome against the reference (George Church)
python3 skills/genome-compare/genome_compare.py \
  --input <23andme_file> \
  --output <report_dir>

# Demo mode (Corpas vs Church)
python3 skills/genome-compare/genome_compare.py \
  --demo \
  --output <report_dir>

Argument	Required	Description
--input	Yes*	Path to 23andMe raw data file
--output	Yes	Output directory for report and figures
--demo	No	Run built-in Corpas vs Church comparison

*Not required when using --demo.

Output

• report.md -- Pairwise comparison report with IBS score and ancestry estimates
• figures/ -- IBS distribution plots, chromosome-level similarity
• tables/ -- Per-chromosome IBS breakdown (CSV)
• commands.sh -- Reproducibility script
• checksums.sha256 -- Output verification